Bone Metabolism (C-BM)
Membership
Name | Position | Country | Term | Time in Office |
E. Cavalier | Chair | BE | 1st | 2019 01 - 2021 12 |
H.P. Bhattoa | Member | HU | 1st | 2019 02 - 2021 12 |
A. Heijboer | Member | NL | 1st | 2019 02 - 2021 12 |
C. Ulmer | Member | US | 1st | 2019 02 - 2021 12 |
S. Vasikaran | Member | AU | 1st | 2019 02 - 2021 12 |
V. Delatour | Consultant | FR | | |
K. Phinney | Consultant | US | | |
C. Sempos | Consultant | US | | |
C. Sturgeon | Consultant | UK | | |
H. Vesper | Consultant | US | | |
As of January 2019 the IFCC has recently created a Committee on “Bone Metabolism (C-BM)”, formed by the joining of the already existing Working Groups:
- Standardization of Bone Markers Assays (WG-BMA) in collaboration with IOF
- Parathyroid Hormone (WG-PTH)
- Vitamin D Standardization Program (WG-Vit D)
The Terms of Reference
- Standardize PTH assays
- Standardize or harmonize bone markers assays
- Standardize vitamin D metabolites assays
Current Projects
1. PTH assays
- Create liaison with International Endocrinological, Rheumatological and Nephological organizations
- Define the measurand (what we need to measure for all clinical situations)
- Develop a reference measurement procedure for PTH(1-84) and moieties of clinical interest
- Evaluate the commutability of PTH International standard PTH 95/646 and the need to create primary reference material
- Replicate the RMP in a second lab and create a network of 3-4 reference labs
- Create an accuracy-based external quality assessment scheme
- Constitute an appropriate and international panel of sera and plasma to establish PTH reference intervals
- Specify performance criteria for RMP and routine methods
- Provide services to manufacturers, notably by providing a reliable source for primary reference materials
- Post-survey of the standardization effects
2. Bone markers assays
- Continue the liaison with IOF and extend to other relevant international societies
Current CTX and PINP project:
- complete the multicenter study and harmonize CTX and PINP assays
- Collaborate with EQAS provider(s) to improve the surveys
- Constitute an appropriate and international panel of sera and plasma to establish CTX and PINP reference intervals
- Post-survey of the standardization/harmonization effects.
Future projects:
- Select biomarkers to be standardized/harmonized (g.: bone alkaline phosphatase, FGF-23, sclerostin).
3. Vitamin D metabolites
- Re-evaluate current VDSP performance guidelines for 25(OH)D
- Establish VDSP performance guidelines for 24,25(OH)2D, C3-epimer and vitamin D binding protein
- Post-survey of the standardization effects
- Propose services to reassess the true value of 25OHD obtained in former epidemiological or interventional studies that had used non-standardized methods
List of Corresponding Members, nominated by National Societies
Name | Full and Affiliate Member Societies |
M. Herrmann | Austrian Society of Laboratory Medicine and Clinical Chemistry (ÖGLMKC) |
JP. Cristol | Société Française de Biologie Clinique (SFBC) |
E. Delvin | Canadian Society of Clinical Chemists (CSCC) |
G. Lombardi | Italian Society of Clinical Chemistry and Clinical Molecular Biology (SIBioC) |
M. Miura | Japan Society of Clinical Chemistry (JSCC) |
R. Pikner | Czech Society of Clinical Biochemistry (CSKB) |
N. Rye Joergensen | Danish Society of Clinical Biochemistry (DSKB) |
A. Sepici Dinçel | Turkish Biochemical Society (TBS) |
G. Zemtsovskaja | Estonian Society for Laboratory Medicine |
List of Corresponding Members, nominated by Corporate Members
Name | Corporate Member |
G. Avery | ABBOTT |
C. Vogl | ROCHE Diagnostics GmbH |
K. Machida | NITTOBO Medical Co. Ltd. |
N. Parker | SIEMENS Healthcare Diagnostics, Inc. |
Committee Chair's contact
Prof Etienne Cavalier, PhD, EuSpLM
Head, Department of Clinical Chemistry
University of Liège, CHU de Liège
Route 52, Porte 53
Domaine du Sart-Tilman
B-4000 Liège, Belgium
Tel: +32 4 366 88 22 or 76 92
Fax:+32 4 366 88 23
E-mail: etienne.cavalier@chu.ulg.ac.be